Propargylamine → N-[3-(2,4-Dichlorophenoxy)propyl]prop-2-yn-1-amine
Reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH2:6][CH2:7]Br.[CH2:14]([NH2:17])[C:15]#[CH:16]>CC#N.O>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH:17][CH2:14][C:15]#[CH:16]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
2.3 ml of 87% pure 3-(2,4-dichlorophenoxyl) propylbromide (2.99 g; 0.011 mole) and 1.6 ml propargylamine (1.38 g; 0.025 mole) in 30 ml CH3CN and 1.65 g k2CO3 in 3 ml H2O were stirred at room temperature for 5 days.
Sources & evidence
- ORD record
- ord-7cf97d5e7fe44f1e8bd3165edd7751f9
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04913891
Reaction notes
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