Hydrogen Bromide → 3,3'-Difluoro-4,4'-dihydroxybiphenyl
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[C:12]([F:18])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.Br>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([F:18])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[OH:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
10.0 g of 3,3'-difluoro-4,4'-dimethoxybiphenyl was dissolved in 150 ml of dioxane, and 150 ml of 48% hydrobromic acid was added. The mixture was heated under reflux for 50 hours. After the reaction, the reaction mixture was subjected to evaporation under reduced pressure. The residue was fully washed with water to obtain the desired 3,3'-difluoro-4,4'-dihydroxybiphenyl.
Workup
- temperatureThe mixture was heated
- temperatureunder reflux for 50 hours
- customAfter the reaction
- customthe reaction mixture was subjected to evaporation under reduced pressure
- washThe residue was fully washed with water
Sources & evidence
- ORD record
- ord-22eec997dd984271a95b2777c6cc5e19
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04914224
Reaction notes
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