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Triethylamine → N-(4-benzyloxy-2,2-difluorobutyl)-p-toluenesulfonamide

HRID 2072886
Notes
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Reaction equation

HRID 2072886 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][C:11]([F:15])([F:14])[CH2:12][NH2:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N([CH2:21][CH3:22])CC)C.[C:23]1(C)[C:24]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:26]=C[CH:28]=1>ClCCl.CCOCC>[CH2:1]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:15])[CH2:12][NH:13][S:29]([C:24]1[CH:25]=[CH:26][C:21]([CH3:22])=[CH:28][CH:23]=1)(=[O:31])=[O:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 8623o-Toluenesulfonyl chlorideHCID 198606944-Benzyloxy-2,2-difluorobutylamine

Product 1

HCID 19860703N-(4-benzyloxy-2,2-difluorobutyl)-p-toluenesulfonamide

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent
HCID 6344
Dichloromethane
Solvent
2×

Procedure

To a solution of 4-benzyloxy-2,2-difluorobutylamine (5.16 g, 20.5 mM) and triethylamine (4.4 g, 43.4 mM) in dry dichloromethane is added toluenesulfonyl chloride (4.14 g, 21.7 moles). The mixture is stirred at room temperature overnight. Additional dichloromethane is added, and the organic phase is washed with 1N HCl followed by a water wash. Drying (Na2SO4) and evaporation of the solvent yields a white solid which is dissolved in a small volume of ether. Addition of petroleum ether yields the compound, N-(4-benzyloxy-2,2-difluorobutyl)-p-toluenesulfonamide as white crystals: 7.0 g (92%).

Workup

  1. washthe organic phase is washed with 1N HCl
  2. washwash
  3. customDrying
  4. custom(Na2SO4) and evaporation of the solvent
  5. customyields a white solid which

Sources & evidence

ORD record
ord-c18af4d76dc849879951f3387af9ad07
Source dataset
uspto-grants-1990_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04914240

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes