Ammonia → 5-Acetyl-2-amino-6-methyl-3-pyridinecarbonitrile
Reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](Cl)=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].[NH3:14]>O1CCCC1>[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7]([NH2:14])=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
40 g (0.21 mol) of 5-acetyl-2-chloro-3-cyano-6-methyl-pyridine are dissolved in 800 ml of tetrahydrofuran, 200 ml of concentrated aqueous NH3 solution are added, and the mixture is heated at 80° C. in a stirred autoclave for two hours. After cooling, the mixture is concentrated and filtered, and the filter cake is extracted by boiling in acetonitrile and is filtered with suction.
Workup
- temperatureAfter cooling
- concentrationthe mixture is concentrated
- filtrationfiltered
- extractionthe filter cake is extracted
- filtrationis filtered with suction
Sources & evidence
- ORD record
- ord-88e94102938145fe8ab76c4a08d35e07
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04920136
Reaction notes
Loading…