Hydrochloric Acid → HCID 14233599, compound
Reaction equation
[NH2:1][C:2]1[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O)C.[ClH:17]>C(OCC)C>[ClH:17].[NH2:1][C:2]1[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
At room temperature, a solution of 3.09 g (0.0127 mol) of ethyl 2-amino-4-bromobenzoate and 30 ml absolute ethanol was saturated with dry hydrogen chloride gas. A colorless precipitate formed in the warm solution. When it was again at room temperature, the solution was diluted with 30 ml of diethyl ether; the resulting crystalline product was filtered and washed with diethyl ether. Thus there was obtained 2.72 g (77%) of the title compound: m.p. 147°-150° C.
Workup
- customAt room temperature
- customA colorless precipitate formed in the warm solution
- customwas again at room temperature
- filtrationthe resulting crystalline product was filtered
- washwashed with diethyl ether
Sources & evidence
- ORD record
- ord-c7f69e954fd1492bafc649b48b31c194
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04920224
Reaction notes
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