Thionyl Chloride → alpha-(3-Chloromethylphenoxy)acetonitrile
Reaction equation
O[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9].S(Cl)([Cl:15])=O>C(OCC)C.CN(C)C=O>[Cl:15][CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
α-(3-Hydroxymethylphenoxy)acetonitrile (0.055 mol) in diethylether (150 ml) is stirred with thionyl chloride (0.060 ml) and a few drops of dimethylformamide at 40° C. for 1 hr. The solution is washed with water and brine, then evaporated to give α-(3-chloromethylphenoxy)acetonitrile as a yellow oil which is used directly in the next step.
Workup
- washThe solution is washed with water and brine
- customevaporated
Sources & evidence
- ORD record
- ord-66aa89bd7e174ccc938c806af75fcc0f
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04920132
Reaction notes
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