Bromide ion → Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol

Reaction equation

[Br-:14].[CH:15]1([Mg+:18])[CH2:16][CH2:17]1.[Cl:19][c:20]1[cH:21][c:22]([F:23])[c:24]([CH:25]([CH:26]2[CH2:27][CH2:28]2)[OH:29])[c:30]([F:31])[cH:32]1.[F:1][C:2]1([F:13])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([CH:11]=[O:12])[cH:10]2)[O:6]1.[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[F:1][C:2]1([F:13])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([CH:11]([OH:12])[CH:15]3[CH2:16][CH2:17]3)[cH:10]2)[O:6]1

Participants

Reactant 5

HCID 259Bromide ion

HCID 8028Tetrahydrofuran

HCID 27369732,2-Difluoro-5-formylbenzodioxole

HCID 58392245(4-Chloro-2,6-difluorophenyl)(cyclopropyl)methanol

HCID 178507030HCID 178507030, compound

Product 1

HCID 58392116Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol

Sources & evidence

ORD record: ord-cdddf81bb97c48e8843416e737d28e89
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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