Urea → HCID 178517453, compound

HRID 2079626

Reaction equation

HRID 2079626 reaction equation
[NH2:1][C:2]1[C:7](Cl)=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:10]O.[NH2:12][C:13](N)=[O:14]>O>[OH:14][C:13]1[N:12]=[CH:10][C:3]2[C:2](=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:1]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 67080684(2-Amino-5-bromo-3-chlorophenyl)methanol

Product 1

HCID 178517453HCID 178517453, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (3.3 g, obtained from step 3) and urea (10.5 g, 15 equiv.) was heated to 180° C. with vigorous stirring for 1 hr. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 2-hydroxyquinazoline as a yellow powder (2.18 g, crude). ES/MS m/z 259/261 (MH+).

Workup

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationThe solid was collected by filtration
  3. customAir-dried

Sources & evidence

ORD record
ord-aa91e9504bab4eaa9adb9c8601ef4982
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Linked notes

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