Imidazole → (S)-4-(t-Butyldimethylsilyloxy)pyrrolidin-2-one
Reaction equation
N1C=CN=C1.[C:6]([Si:10]([CH3:13])([CH3:12])Cl)([CH3:9])([CH3:8])[CH3:7].CN(C)C=O.[OH:19][C@@H:20]1[CH2:24][NH:23][C:22](=[O:25])[CH2:21]1>O>[Si:10]([O:19][C@@H:20]1[CH2:24][NH:23][C:22](=[O:25])[CH2:21]1)([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:13])[CH3:12]Participants
6
Procedure
1.02 g of imidazole and 1.58 g of t-butyldimethylchlorosilane were added to a dimethylformamide (5 ml) solution of 1.01 g of (S)-4-hydroxy-2-pyrrolidone, and stirred overnight at room temperature. Water was added to the reaction liquid, and stirred with cooling with ice.
Workup
- stirringstirred
- temperaturewith cooling with ice
Sources & evidence
- ORD record
- ord-dfda37379d9449df9a9343bbd05bd9f2
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07932394B2
Reaction notes
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