Cyclopentanone → HCID 59347806, compound
Reaction equation
Cl.[CH3:2][O:3][CH2:4][CH2:5][NH:6][CH3:7].C1(=O)CCCC1.[C-]#N.[K+].CN(C)[C:19]1([C:24]#[N:25])[CH2:23][CH2:22][CH2:21][CH2:20]1>O>[CH3:7][N:6]([CH2:5][CH2:4][O:3][CH3:2])[C:19]1([C:24]#[N:25])[CH2:23][CH2:22][CH2:21][CH2:20]1Participants
6
Procedure
The title compound (3.39 g; 82%) was prepared from N-(2-methoxyethyl)methylamine hydrochloride (2.84 g; 22.6 mmol), cyclopentanone (1.90 g, 22.6 mmol) and potassium cyanide (1.47 g; 22.6 mmol) in water (15 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.83 (6H, m). 2.20 (2H, m), 2.48 (3H, s), 2.68 (2H, t), 3.46 (3H, s), 3.5 (2H, t).
Sources & evidence
- ORD record
- ord-e3b63cb316884a4c9f6038e4082ef5cd
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07745642B2
Reaction notes
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