Acetic Anhydride → HCID 15023231, compound

Reaction equation

[NH2:1][CH2:2][CH:3]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[O:6][CH2:5][CH2:4]1.[CH2:15](OC=O)[CH3:16].C(OC(=O)C)(=O)C>>[CH2:15]([NH:1][CH2:2][CH:3]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[O:6][CH2:5][CH2:4]1)[CH3:16]

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 8025Ethyl formate

HCID 15023228HCID 15023228, compound

Product 1

HCID 15023231HCID 15023231, compound

Procedure

The product from Example 2 was reacted as described in Example 3 replacing ethylformate with acetic anhydride, giving the desired product, (M+H)+ 222. 1H NMR(CDCl3): 1.15 (t,3H); 2.05 (m,2H); 2.6-2.0 (m,4H); 3.75 (s,3H); 4.2 (m,1H), 6.3-7.1 (m,3H).

Sources & evidence

ORD record: ord-a77e387529c243b284128fd661004854
Source dataset: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05185364

Reaction notes

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