Methanol → HCID 20360307, compound

Reaction equation

ICC.[CH3:4][O-:5].[Na+].[CH2:7]([O:9][C:10]1[CH:18]=[CH:17][C:16](OC)=[CH:15][C:11]=1[C:12]([NH2:14])=[O:13])[CH3:8].[CH3:21][OH:22]>>[C:4]([C:16]1[CH:17]=[CH:18][C:10]([O:9][CH2:7][CH3:8])=[C:11]([CH:15]=1)[C:12]([NH2:14])=[O:13])([O:22][CH3:21])=[O:5]

Participants

Reactant 4

HCID 887Methanol

HCID 6340Iodoethane

HCID 10942334Sodium Methoxide

HCID 20360292HCID 20360292, compound

Product 1

HCID 20360307HCID 20360307, compound

Procedure

5-Carbomethoxy-2-ethoxybenzamide (m.p. 159°-161° ) was prepared from 5-carbomethoxysalicylamie, iodoethane, and sodium methoxide in methanol in a manner analogous to that described for the preparation of 2-ethoxy-5-methoxybenzamide in Preparation 14A.

Sources & evidence

ORD record: ord-cb886337b2bb43d7958967cf982e721d
Source dataset: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04082751

Reaction notes

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