Ethyl Acetate → HCID 69889187, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[S:8][CH2:7][CH2:6][C:5]2([C:13]([OH:15])=[O:14])[OH:12].CCCCCCC.C(OCC)(=O)C>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[S:8][CH2:7][CH2:6][C@@:5]2([C:13]([OH:15])=[O:14])[OH:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The enantiomers of 6-chloro-4-hydroxythiochromane-4-yl-carboxylic acid (1.4 g, 5.7 mmol; from step (iii) above) were separated using chiral chromatography (Kromasil TBB; heptane: ethyl acetate: formic acid) yielding 0.500 g (71%) of the slower moving sub-title compound.
Workup
- customyielding 0.500 g (71%) of the
Sources & evidence
- ORD record
- ord-ba1b12e1521a4b62bd31f5649083ffd3
- Source dataset
- uspto-grants-2004_04
- Patent number
- US06716834B2
Reaction notes
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