Benzeneacetic acid, 2-fluoro- → HCID 10728612, compound

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[K+].[CH3:25][CH:26](C([O-])=O)[C:27]([O:29][CH2:30][CH3:31])=[O:28].[Cl-].[Mg+2].[Cl-]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:11])[CH:26]([CH3:25])[C:27]([O:29][CH2:30][CH3:31])=[O:28]

Participants

Reactant 4

HCID 67979Benzeneacetic acid, 2-fluoro-

HCID 682631,1'-Carbonyldiimidazole

HCID 5360315Magnesium Chloride

HCID 23679020HCID 23679020, compound

Product 1

HCID 10728612HCID 10728612, compound

Procedure

That is, 2-fluorophenylacetic acid (4) and 1,1′-carbonyldiimidazole (CDI) are reacted, followed by treatment with ethyl methylmalonate mono potassium salt in the presence of magnesium chloride to obtain ethyl 4-(2-fluorophenyl)-2-methyl-3-oxobutyrate (5).

Sources & evidence

ORD record: ord-fc00ac4136334554abc7861439ebf569
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06717016B2

Reaction notes

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