Acetone Cyanohydrin → 2-Methyl-2-(piperidin-1-yl)propan-1-amine

Reaction equation

O[C:2]([CH3:6])([CH3:5])[C:3]#[N:4].[NH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>>[NH2:4][CH2:3][C:2]([N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)([CH3:6])[CH3:5]

Participants

Reactant 2

HCID 6406Acetone Cyanohydrin

HCID 8082Piperidine

Product 1

HCID 17131182-Methyl-2-(piperidin-1-yl)propan-1-amine

Procedure

The starting material 1-(2-amino-1,1-dimethylethyl)piperidine was prepared in a route similar to that in Example 39 from 2-hydroxy-2-methyl-propionitrile and piperidine.

Sources & evidence

ORD record: ord-eb91565041dd4269a0f9ad987afe38a8
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06720346B2

Reaction notes

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