Phenylacetone → 3-(4-Bromophenyl)-4-(4-methylthiophenyl)-3-buten-2-one

HRID 2086740Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1.CC1C=CC([CH:17]=[S:18])=CC=1.[C:21]1([CH2:27]C(=O)C)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.BrC1C=CC(C=O)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[CH:27][C:21]2[CH:26]=[CH:25][C:24]([S:18][CH3:17])=[CH:23][CH:22]=2)[C:9](=[O:11])[CH3:10])=[CH:6][CH:7]=1

Participants

Reactant 4

HCID 7678Phenylacetone

HCID 707414-Bromobenzaldehyde

HCID 7363321-(4-Bromophenyl)propan-2-one

HCID 181775354-Methylthiobenzaldehyde

Product 1

HCID 540939353-(4-Bromophenyl)-4-(4-methylthiophenyl)-3-buten-2-one

Procedure

The title compound was prepared according to the procedure of step 1 in the Example 190 using (4-bromophenyl)acetone and 4-methylthiobenzaldehyde, instead of phenylacetone and 4-bromobenzaldehyde.

Sources & evidence

ORD record: ord-6b8e7a89540941259c61c08427a43d46
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06727238B2

Reaction notes

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