Hydrazine hydrate (1:1) → N-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087802

Reaction equation

HRID 2087802 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:25]=[C:26]([NH:30][C:31](=[O:35])[CH:32]([CH3:34])[CH3:33])[CH:27]=[CH:28][CH:29]=2)[CH2:20][CH2:19]1.O.NN>>[NH2:3][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:25]=[C:26]([NH:30][C:31](=[O:35])[CH:32]([CH3:33])[CH3:34])[CH:27]=[CH:28][CH:29]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 16757364N-(3-{1-[6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Product 1

HCID 16755868N-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure AE and Scheme Y using N-(3-{1-[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide and hydrazine hydrate: ESMS m/e: 346.2 (M+H)+.

Workup

  1. customPrepared by Procedure AE and Scheme Y

Sources & evidence

ORD record
ord-decc669942d84f71b6eae10ba931bf70
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Linked notes

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