Trifluoroacetic acid → N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

HRID 2089131Notes

Reaction equation

HRID 2089131 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1)=O)(C)(C)C.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>C(Cl)Cl>[OH:36][C:30]([C:32]([F:35])([F:34])[F:33])=[O:31].[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:26])([F:28])[F:27])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 674789043-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86660176N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester (500 mg, 1.21 mmol) in DCM (5 mL) and TFA (5 mL) was stirred at room temperature for 1 hour. The solvent was removed and then lyophilized overnight to give the title compound as colorless oil.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-da8966db0cee432a98f071861064bc60
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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