Hydrazine → 3-Amino-5-trifluoromethyl-indazole-1-carboxylic acid tert-butylamide
Reaction equation
[C:1]([NH:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:15]=2)[C:10]([N:21]2C(=O)C3C(=CC=CC=3)C2=O)=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].NN>C1COCC1>[C:1]([NH:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:20])([F:18])[F:19])=[CH:14][CH:15]=2)[C:10]([NH2:21])=[N:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Participants
4
Procedure
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide (1.41 g, 3.28 mmol) in THF (5 mL) was treated with hydrazine (315 mg, 9.84 mmol) at room temperature for 30 min. The solvent was removed and the residue was purified by silica gel column chromatography using 1:1 hexanes and ethyl acetate to afford the title compound as white solid.