Hydrochloric Acid → 7-(Piperazin-1-yl)-4-(pyrrolidin-1-yl)quinazoline dihydrochloride
Reaction equation
[N:1]1([C:6]2[C:15]3[C:10](=[CH:11][C:12]([N:16]4[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]4)=[CH:13][CH:14]=3)[N:9]=[CH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:29]>CO>[ClH:29].[ClH:29].[N:16]1([C:12]2[CH:11]=[C:10]3[C:15]([C:6]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[N:7][CH:8]=[N:9]3)=[CH:14][CH:13]=2)[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1Participants
4
Procedure
tert-butyl 4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazine-1-carboxylate (B) (130 mg, 0.339 mmol) was dissolved at room temperature in methanol (2 ml), and then hydrogen chloride (2.71 ml, 3.39 mmol, 1.25 M solution in methanol) was added. The reaction mixture was refluxed for 1 h and then stirred for 15 h at room temperature. Concentration in vacuo was carried out, and the residue was taken up in a small amount of ethanol and heated. Diethyl ether was then added, the mixture was cooled in an ice bath, and finally the resulting solid was filtered off.