Triethylamine → HCID 86670212, compound

To a 0° C. solution of (1R,2R)-2-methylcyclopropanecarboxylic acid (2.0 g, 20.0 mmol) in anhydrous acetone (100 mL) was added triethylamine (2.87 mL, 20.6 mmol) and ethyl chloroformate (1.96 mL, 20.6 mL). The cold bath was removed and the reaction was allowed to warm to room temperature for 30 min before the addition of sodium azide (1.36 g, 21.00 mmol) in water (20 mL). The reaction was maintained at room temperature for 1 h, then diluted with DCM (300 mL) and water (200 mL). The layers were separated and the organic was washed with water (2×100 mL) and brine (100 mL) then dried over MgSO4 and concentrated to provide (1R,2R)-2-methylcyclopropanecarbonyl azide (1.8 g, 72% yield) which was used directly in the next reaction. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.47-1.58 (m, 1H), 1.35-1.42 (m, 1H), 1.28-1.34 (m, 1H), 1.14 (d, J=6.0 Hz, 3H), 0.79-0.87 (m, 1H).

1. customThe cold bath was removed
2. customThe layers were separated
3. washthe organic was washed with water (2×100 mL) and brine (100 mL)
4. dry with materialthen dried over MgSO4
5. concentrationconcentrated

ORD record

ord-183a408fa0ee4ace8a6227b845749a81

Source dataset

uspto-grants-2013_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08440652B2