Hydrochloric Acid → 2-[(3-Oxo-2,3-dihydropyridazin-4-yl)methyl]isoindoline-1,3-dione
Reaction equation
C[O:2][C:3]1[N:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]1=[O:20].Cl>O1CCOCC1>[O:2]=[C:3]1[C:8]([CH2:9][N:10]2[C:11](=[O:20])[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:18]2=[O:19])=[CH:7][CH:6]=[N:5][NH:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-[(3-Methoxypridazin-4-yl)methyl]isoindoline-1,3-dione (1.15 g, 4.27 mmol) in 1,4-dioxane (90 mL) was refluxed with 12 M hydrochloric acid (2 mL) for 1 hour. After completion of the reaction, the solvent was removed by vacuum distillation to give the desired product (1.1 g, 100% yield).
Workup
- customAfter completion of the reaction
- customthe solvent was removed by vacuum distillation
Sources & evidence
- ORD record
- ord-2046861e8c9f4fa3921da752d1284c5a
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440666B2
Reaction notes
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