Hydrazine hydrate (1:1) → HCID 55285530, compound
Reaction equation
[O:1]=[C:2]1[C:7]([CH2:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:5]=[N:4][NH:3]1.O.NN>CO>[NH2:9][CH2:8][C:7]1[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
2-[(3-Oxo-2,3-dihydropyridazin-4-yl)methyl]isoindoline-1,3-dione (255 mg, 1.00 mmol) in methanol (2 mL) was mixed with hydrazine monohydrate (250 mg, 5.00 mmol) at room temperature and stirred at 60° C. for 3 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give a crude reaction product containing the desired product, which was used for the next step.
Workup
- customAfter completion of the reaction
- filtrationthe solid was filtered off with chloroform
- customthe filtrate was evaporated under reduced pressure repeatedly
- customto give a crude
- customreaction product
Sources & evidence
- ORD record
- ord-89079f8daeeb463581cb0b7bed38ea0a
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440666B2
Reaction notes
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