4-Hydroxybenzaldehyde → 4-(3,3,3-Trifluoro-2-hydroxypropoxy)benzaldehyde
Reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.Br[CH2:11][CH:12]([OH:17])[C:13]([F:16])([F:15])[F:14]>>[F:14][C:13]([F:16])([F:15])[CH:12]([OH:17])[CH2:11][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1Participants
3
Procedure
The title compound is prepared analogously to Example 12A from 4-hydroxybenzaldehyde and 3-bromo-1,1,1-trifluoropropan-2-ol.
Sources & evidence
- ORD record
- ord-a82d7d59227942fcbe589b1acbbe0d44
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440700B2
Reaction notes
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