Lithium Hydroxide → Benzo[d][1,3]dioxol-5-ylglycine
Reaction equation
C([O:3][C:4](=[O:16])[CH2:5][NH:6][C:7]1[CH:15]=[CH:14][C:10]2[O:11][CH2:12][O:13][C:9]=2[CH:8]=1)C.[OH-].[Li+]>CO>[O:11]1[C:10]2[CH:14]=[CH:15][C:7]([NH:6][CH2:5][C:4]([OH:16])=[O:3])=[CH:8][C:9]=2[O:13][CH2:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of compound (Benzo[1,3]dioxol-5-ylamino)-acetic acid ethyl ester in methanol was added lithium hydroxide (1.2 eq.) and stirred for overnight. Reaction mixture was then concentrated and neutralized to afford (Benzo[1,3]dioxol-5-ylamino)-acetic acid.
Workup
- customReaction mixture
- concentrationwas then concentrated
Sources & evidence
- ORD record
- ord-f9055fe229f94d2cb1be45b8718fc4a9
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440830B2
Reaction notes
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