Lithium Hydroxide → 3-(2-Chloroethoxy)propanoic acid

HRID 2094308Notes

Reaction equation

HRID 2094308 reaction equation
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([O:9]CC)=[O:8].[OH-].[Li+]>C(O)C>[Cl:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 85848654Ethyl 3-(2-chloro-ethoxy)-propionate

Product 1

HCID 3436803-(2-Chloroethoxy)propanoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.00 g (11.1 mmol) ethyl 3-(2-chloro-ethoxy)-propionate are suspended in 8 ml of ethanol and 4.96 ml (16.6 mmol) of 8% lithium hydroxide solution are added. The mixture is stirred for 4 hours at ambient temperature, then evaporated down i. vac., acidified with 2-molar hydrochloric acid, combined with diethyl ether and dried over sodium sulphate. Then it is filtered off and evaporated down i. vac.

Workup

  1. customevaporated down i
  2. dry with materialdried over sodium sulphate
  3. filtrationThen it is filtered off
  4. customevaporated down i

Sources & evidence

ORD record
ord-70abbf213c354f598da129b70fc1419a
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

Loading…