Hydroxyamine hydrochloride → HCID 76688560, compound

A 50% aqueous solution of hydroxylamine hydrochloride (9 mL, 64.8 mmol) was added to a stirred suspension of 2-fluoro-3-iodobenzaldehyde (preparation 22d, 2.10 g, 8.4 mmol) in ethanol (10 mL) and the mixture was warmed slightly until a solution was formed. After stirring for 3 days at room temperature, the mixture was concentrated in vacuo and water was added to the residue. The mixture was extracted with ethyl acetate and the organic layer was washed with brine, dried (MgSO4) and evaporated to give the title compound (2.15 g, 97%) as a solid.

1. temperaturethe mixture was warmed slightly until a solution
2. customwas formed
3. concentrationthe mixture was concentrated in vacuo and water
4. additionwas added to the residue
5. extractionThe mixture was extracted with ethyl acetate
6. washthe organic layer was washed with brine
7. dry with materialdried (MgSO4)
8. customevaporated

ORD record

ord-43a87c5b3b494852bb33b22d56ad74b3

Source dataset

uspto-grants-2013_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08450341B2