Hydrazine hydrate (1:1) → 5-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

HRID 2098039Notes

Reaction equation

HRID 2098039 reaction equation
[Cl:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.O.[NH2:13][NH2:14]>C(O)C>[Cl:1][C:2]1[C:10]2[C:9]([NH:13][NH2:14])=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 157457684,5-Dichlorothieno[2,3-d]pyrimidine

Product 1

HCID 157460705-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Chloro-4-chlorothieno[2,3-d]pyrimidine (1.38 g, 6.73 mmol) and hydrazine monohydrate (5.0 ml, 103 mmol) in absolute ethanol (20 ml) were heated at 75° C. After stirring for 24 h, the solution was concentrated to yield 5-chloro-4-hydrazinylthieno[2,3-d]pyrimidine. Method [6] Retention time 0.35 min by HPLC (M+=201 and 203).

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-4ef83b4d20f94118b48170ed044cccc0
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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