Ethanol → 4-Chloro-4'-thiocyanatomethylbenzophenone

4-bromomethyl-4'-chlorobenzophenone (5.7 g) and sodium thiocyanate (5.5 g) were added to ethanol (50 ml), and the mixture was stirred for one hour at 60° C. The reaction mixture was concentrated, and water was added to the residue. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with a solvent mixture of n-hexane:ethyl acetate=10:1 to obtain the desired product (2.2 g, melting point: 129° to 131° C., yield:42%).

1. concentrationThe reaction mixture was concentrated
2. additionwater was added to the residue
3. extractionThe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationEthyl acetate was distilled off under reduced pressure
7. washThe residual solid was washed with a solvent mixture of n-hexane

ORD record

ord-39af67312f5442e6ae004f66e6de33ad

Source dataset

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05728699