Iodoethane → 3H-Indolium, 1-ethyl-5-methoxy-2,3,3-trimethyl-, iodide
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[I:15][CH2:16][CH3:17]>ClC1C=CC=CC=1Cl>[I-:15].[CH2:16]([N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])[CH3:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
To 5-methoxy-2,3,3-trimethyl-3H-indole (1.9 g) was added iodoethane (5 ml) and 1,2-dichlorobenzene (10 ml). The mixture was heated to 80° C. for 4 hours after which time the mixture was allowed to cool and the precipitate removed by filtration and washed sequentially with dichlorobenzene and diethyl ether. Drying in a vacuum oven gave the product (3 g).
Workup
- temperatureto cool
- customthe precipitate removed by filtration
- washwashed sequentially with dichlorobenzene and diethyl ether
- customDrying in a vacuum oven
Sources & evidence
- ORD record
- ord-04936a8e9a6f4d0ca0151ca74ceb186b
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07579140B2
Reaction notes
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