Dabco → 1-(4-{4-[3-[3-(4-Fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]-phenoxymethyl}-benzyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide

HRID 2105732

Reaction equation

HRID 2105732 reaction equation
[Br:1][CH2:2][C:3]1[CH:40]=[CH:39][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:18]([C:19]4[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=4)[CH:17]([CH2:27][CH2:28][CH:29]([C:31]4[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=4)[OH:30])[C:16]3=[O:38])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[CH2:41]1[N:46]2[CH2:47][CH2:48][N:43]([CH2:44][CH2:45]2)[CH2:42]1>C1(C)C=CC=CC=1>[Br-:1].[F:37][C:34]1[CH:35]=[CH:36][C:31]([CH:29]([OH:30])[CH2:28][CH2:27][CH:17]2[C:16](=[O:38])[N:15]([C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]4[CH:39]=[CH:40][C:3]([CH2:2][N+:43]56[CH2:48][CH2:47][N:46]([CH2:45][CH2:44]5)[CH2:41][CH2:42]6)=[CH:4][CH:5]=4)=[CH:10][CH:11]=3)[CH:18]2[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 9237DabcoHCID 210831671-[4-(4-Bromomethylbenzyloxy)-phenyl]-3-[3-(4-fluorophenyl)-3-hydroxypropyl]4-(4-methoxyphenyl)-azetidin-2-one

Product 1

HCID 210831631-(4-{4-[3-[3-(4-Fluorophenyl)-3-hydroxypropyl]-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]-phenoxymethyl}-benzyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Compound (25) and DABCO were dissolved in toluene and reacted analogously to Example IV, giving the product (26) as a colorless solid of molecular weight 716.70 (C39H43BrFN3O4); MS (ESI): 636.3 (MH+).

Workup

  1. customreacted analogously to Example IV

Sources & evidence

ORD record
ord-a0c4a659c15a4886a2686d4f6966de97
Source dataset
uspto-grants-2009_08
Patent number
US07579339B2

Linked notes

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