Tert-Butylamine → N-(tert-butyl)-2-piperazin-1-ylacetamide

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([NH:23][C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)([CH3:22])([CH3:21])[CH3:20]

Participants

Reactant 3

HCID 6385Tert-Butylamine

HCID 6577Chloroacetyl chloride

HCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 2468184N-(tert-butyl)-2-piperazin-1-ylacetamide

Procedure

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetyl-chloride and N-tert-butylamine in an analogous manner as described in example 21.

Sources & evidence

ORD record: ord-654eb650546a4a93b4d1d91ca073fbf6
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579368B2

Reaction notes

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