Hydrochloric Acid → 5-(2-Aminothiazol-4-ylmethylene)thiazolidine-2,4-dione hydrochloride
Reaction equation
C([NH:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[C:27]2[S:31][C:30](=[O:32])[NH:29][C:28]2=[O:33])[N:25]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:34]>O1CCOCC1>[ClH:34].[NH2:20][C:21]1[S:22][CH:23]=[C:24]([CH:26]=[C:27]2[S:31][C:30](=[O:32])[NH:29][C:28]2=[O:33])[N:25]=1Participants
4
Procedure
Following a procedure similar to that described in Example 21, the desired compound was prepared from 1.4 g of 5-(2-tritylaminothiazole-4-ylmethylene)thiazolidine-2,4-dione and 25 ml of a 4N dioxane solution of hydrogen chloride. The resulting product was a pale brown powder having the following physical properties.
Sources & evidence
- ORD record
- ord-f66593f1787548f693d97f3dec9f9cdc
- Source dataset
- uspto-grants-1990_06
- Patent number
- US04933355
Reaction notes
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