Triethylamine → 2-Cyclohexylaminothiazole-4-carbaldehyde
Reaction equation
[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C>CS(C)=O>[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The reaction described in Preparation 44 was repeated, but using 10 g of 2-cyclohexylaminothiazol-4-ylmethanol, 22.4 g of sulfur trioxide pyridine complex, 14.3 g of triethylamine and 100 ml of dimethyl sulfoxide, giving the title compound as a pale brown oil.
Workup
- customThe reaction described in Preparation 44
Sources & evidence
- ORD record
- ord-439cffc706314df7814634ffac8a5f0a
- Source dataset
- uspto-grants-1990_06
- Patent number
- US04933355
Reaction notes
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