Hydrochloric Acid → HCID 19596036, compound

HRID 2107332Notes

Reaction equation

HRID 2107332 reaction equation
C(N[C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8]O)C(C)C.[ClH:14]>>[ClH:14].[CH2:8]([Cl:14])[C:7]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10130218Benzenemethanol, 2-[(2-methylpropyl)amino]-

Product 1

HCID 19596036HCID 19596036, compound

Conditions

Temperature
100 °C

Procedure

In 190 ml of conc. hydrochloric acid was dissolved 19.1 g of 2-(isobutylamino)benzyl alcohol, and the solution was heated in a sealed tube at 100° C. for 40 min. The reaction mixture was stirred for 30 min. under chilling with ice and the precipitated crystals were collected by filtration. The collected crystals were washed successively with hydrochloric acid and acetone and dried to give 16.9 g (yield: 68%) of 2-isobutylamino)benzyl chloride hydrochloride as a white crystalline product.

Workup

  1. temperatureunder chilling with ice
  2. filtrationthe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed successively with hydrochloric acid and acetone
  4. customdried

Sources & evidence

ORD record
ord-2f48c1eda2f1400487a0a32712c6eecd
Source dataset
uspto-grants-1990_06
Patent number
US04933458

Reaction notes

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