Ethyl Acetoacetate → 5-Methyl-1-pyridin-2-yl-1H-pyrazole-4-carbaldehyde

HRID 2109250

Reaction equation

C(OCC)(=O)CC(C)=O.[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][NH2:17].[CH:18]1([C:21]2N(C(C)C)N=[CH:23][C:22]=2[CH:29]=[O:30])CC1>>[CH3:18][C:21]1[N:16]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][N:10]=2)[N:17]=[CH:23][C:22]=1[CH:29]=[O:30]

Participants

Reactant 3

HCID 8868Ethyl Acetoacetate

HCID 786452-Hydrazinopyridine

HCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 210973525-Methyl-1-pyridin-2-yl-1H-pyrazole-4-carbaldehyde

Procedure

5-Methyl-1-pyridin-2-yl-1H-pyrazole-4-carbaldehyde was prepared from ethyl acetoacetate and 2-pyridyl hydrazine in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record: ord-3060dd62999149898f6d6c90c37b0526
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514458B2

Linked notes

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