Hydrazine hydrate (1:1) → Furan-3-carbohydrazide
Reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8]CC)=O)=[CH:2]1.O.[NH2:12][NH2:13]>C(O)C>[O:1]1[CH:5]=[CH:4][C:3]([C:6]([NH:12][NH2:13])=[O:8])=[CH:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl 3-furancarboxylate (7.0 g) and hydrazine monohydrate (4.8 ml) in ethanol (10 ml) were heated at reflux while stirring for 6 hours. The solvent was evaporated under reduced pressure, and the thus-precipitated crystals were recrystallized from ethanol, thereby giving 3.2 g of the desire compound.
Workup
- temperatureat reflux
- customThe solvent was evaporated under reduced pressure
- customthe thus-precipitated crystals were recrystallized from ethanol
Sources & evidence
- ORD record
- ord-76b8ed65192e48999c9b1110a39677d1
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07514452B2
Reaction notes
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