Ammonia → 1-(Quinolin-4-yl)ethan-1-amine

Reaction equation

[N:1]1C=CC=C(C(N)C)C=1.[N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([C:20](=O)[CH3:21])=[CH:12][CH:11]=1.N.CO.C([BH3-])#N.[Na+]>C(O)(=O)C>[N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]([NH2:1])[CH3:21])=[CH:12][CH:11]=1

Participants

Reactant 5

HCID 222Ammonia

HCID 887Methanol

HCID 27716881-(Pyridin-3-yl)ethan-1-amine

HCID 5003444Sodium cyanoborohydride

HCID 123401901-(Quinolin-4-yl)ethan-1-one

Product 1

HCID 108449271-(Quinolin-4-yl)ethan-1-amine

Reagents, catalysts & solvents 1

Procedure

The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-quinolin-4-yl-ethanone, (1.71 g, 10 mmol, Aldrich), 2 M ammonia solution in methyl alcohol, (40 mL, 80 mmol, Aldrich), acetic acid (10 mL, J. T. Baker) and sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich). The title compound obtained in form as light yellow solid in 100% yield (1.72 g, 10 mmol).