Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester → Ethyl 4-chloroacetoacetate

Reaction equation

[Cl:1][CH2:2][CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].C[Si](Cl)C>>[Cl:1][CH2:2][C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

Reactant 2

HCID 4377704Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester

HCID 6327132Chlorodimethylsilane

Product 1

HCID 69484Ethyl 4-chloroacetoacetate

Procedure

The quantitation of ethyl 4-chloro-3-hydroxybutyrate was carried out by gas chromatography. Thus, using a glass column (ID 3 mm×1 m) packed with PEG-20M Chromosorb WAW DMCS 10%, 80/100 mesh (product of GL Sciences Inc.), chromatography was carried out at 150° C. The detection was made by FID.

Workup

customwas carried out at 150° C

Sources & evidence

ORD record: ord-1c63baaa7b784e589ea1319894e1fcf4
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07432095B2

Reaction notes

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