Thionyl Chloride → 3-(3,4-Difluorophenyl)propanoyl chloride
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[F:13])[CH:5]=[CH:6][C:7](O)=[O:8].S(Cl)([Cl:16])=O>ClC(Cl)C.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]([Cl:16])=[O:8])[CH:10]=[CH:11][C:12]=1[F:13]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To 0.27 mol of 3,4-difluorocinnamic acid dissolved in dichloroethane there are added 20 drops of dimethylformamide and 100 ml of thionyl chloride.
Sources & evidence
- ORD record
- ord-e7d404ec0d5e4f63875cfd8f341b6cf5
- Source dataset
- uspto-grants-2008_10
- Patent number
- US07442692B2
Reaction notes
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