4-Aminobenzamide → 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

HRID 2117295

Reaction equation

HRID 2117295 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](S(C)(=O)=O)[N:9]=2)=[CH:4][CH:3]=1.[NH2:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH2:25])=[O:24])=[CH:21][CH:20]=1>CC(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:18][C:19]3[CH:27]=[CH:26][C:22]([C:23]([NH2:25])=[O:24])=[CH:21][CH:20]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 760794-AminobenzamideHCID 219059934-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine

Product 1

HCID 100419644-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 4-(4-chlorophenyl)-2-(methylsulfonyl)pyrimidine (0.10 g, 0.37 mmol) and 4-aminobenzamide in 2-propanol (3 ml) was heated to 120° C. in a sealed vessel for 14 hours. The crude material was concentrated and purified by preparative HPLC to provide the title compound as a beige solid: LC/MS Retention Time; 6.30 min (Method A), M+1; 325.

Workup

  1. concentrationThe crude material was concentrated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-e924f2a7a5884fd39e976a35c0c27c56
Source dataset
uspto-grants-2008_10
Patent number
US07442699B2

Linked notes

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