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Methyl N-(triethylammoniosulfonyl)carbamate → 2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

HRID 2117989
Notes
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Reaction equation

HRID 2117989 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:26](=[CH:27][CH:28]=1)[C:12]1[NH:13][C:14]([C:16]3[C:23]([C:24]#[N:25])=[CH:22][CH:21]=[CH:20][C:17]=3[C:18]#[N:19])=[N:15][C:11]=1[C:10]1[CH:9]=[CH:8][C:7]([C:29]#[C:30][C:31](O)([CH3:33])[CH3:32])=[CH:6][C:5]2=1.CC[N+](S(N=C(OC)[O-])(=O)=O)(CC)CC>C1C=CC=CC=1.CCOC(C)=O>[Cl:1][C:2]1[CH:28]=[CH:27][C:26]2[C:12]3[N:13]=[C:14]([C:16]4[C:17]([C:18]#[N:19])=[CH:20][CH:21]=[CH:22][C:23]=4[C:24]#[N:25])[NH:15][C:11]=3[C:10]3[C:5](=[CH:6][C:7]([C:29]#[C:30][C:31]([CH3:33])=[CH2:32])=[CH:8][CH:9]=3)[C:4]=2[CH:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 2724994Methyl N-(triethylammoniosulfonyl)carbamateHCID 1784590322-(6-chloro-9-(3-hydroxy-3-methylbut-1-ynyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile

Product 1

HCID 866148722-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrileYield 78.2%

Reagents, catalysts & solvents 2

HCID 241BenzeneSolvent
HCID 8857
Ethyl Acetate
Solvent

Procedure

To a stirred suspension of 2-[9-chloro-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile from Example 40 (120 mg, 0.26 mmol) in benzene (4 mL) was added Burgess Reagent (70 mg, 0.29 mmol) and refluxed for 2 hours under N2. The resulting reaction mixture was diluted with EtOAc (20 mL). This EtOAc solution washed with water, brine and dried over MgSO4. After removing the drying agent via filtration, the organic solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluted with 50/50 EtOAc/hexane) to yield 90 mg of 2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile as a yellow solid.

Workup

  1. temperaturerefluxed for 2 hours under N2
  2. customThe resulting reaction mixture
  3. washThis EtOAc solution washed with water, brine
  4. dry with materialdried over MgSO4
  5. customAfter removing the drying agent
  6. filtrationvia filtration
  7. concentrationthe organic solution was concentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography (eluted with 50/50 EtOAc/hexane)

Sources & evidence

ORD record
ord-ffd8789965be40689a6e6ac2799cabad
Source dataset
uspto-grants-2008_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07442716B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes