7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone

HRID 21187

Reaction equation

HRID 21187 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

Participants

5

Reactant 2

HCID 684886597-Amino-4-vinylisoindolinoneHCID 178418361HCID 178418361, compound

Product 1

HCID 684909697-Amino-4-ethylisoindolinoneYield 102.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9b574fe409a9418d963834a7bf341de1
Source dataset
uspto-grants-2010_06
Patent number
US07745641B2

Linked notes

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