7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone
Reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).
Workup
- filtrationThe reaction mixture was filtered
- customthe solvent of the filtrate was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-9b574fe409a9418d963834a7bf341de1
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07745641B2
Reaction notes
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