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2-Chloropyrimidine → 3-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid ethyl ester

HRID 2120706
Notes
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Reaction equation

HRID 2120706 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH:6]([C:15]1[CH:16]=[N:17][C:18]([CH3:21])=[N:19][CH:20]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH3:2].Cl[C:24]1[N:29]=[CH:28][CH:27]=[CH:26][N:25]=1.C(N(CC)C(C)C)(C)C>C(O)C>[O-:3][CH2:1][CH3:2].[NH4+:14].[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH:6]([C:15]1[CH:16]=[N:17][C:18]([CH3:21])=[N:19][CH:20]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:24]1[N:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[CH3:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 744042-ChloropyrimidineHCID 81531DiisopropylethylamineHCID 2062248310-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester

Product 2

HCID 206224843-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid ethyl esterYield 66.5%HCID 22341770NH4OEtYield 1%

Reagents, catalysts & solvents

1
HCID 702EthanolSolvent

Procedure

A solution of 24-7 (360 mg, 1.17 mmol), 2-chloropyrimidine (145 mg, 1.26 mmol), and N,N-diisopropylethylamine (456 mg, 3.53 mmol) in ethanol (5 mL) was heated to 65° C. in a sealed tube (4 days). The solvent was removed in vacuo and the residue diluted in aqueous sodium carbonate and extracted with two portions of dichloromethane. The combined organics were washed with brine and dried (Na2SO4). The solvent was removed in vacuo. PCTLC (SiO2, 4mm, 1% NH4OEt; 10% EtOH; 90% CH2Cl2) afforded 24-8 (150 mg). ESLRMS m/e 386 g/mole (M++H, C21H31N5O2=386 g/mole.)

Workup

  1. customThe solvent was removed in vacuo
  2. additionthe residue diluted in aqueous sodium carbonate
  3. extractionextracted with two portions of dichloromethane
  4. washThe combined organics were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1da75e5ec5944093af75001b29f84e1c
Source dataset
uspto-grants-2004_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06693101B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes