Hydrochloric Acid → HCID 69702667, compound
Reaction equation
[OH:1][CH:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH:13]C(=O)C(C)(C)C.C(O)C.[ClH:24]>O>[Cl-:24].[OH:1][C@H:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH3+:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of the the product from Step B (7.31 g, 2.29 mmol), ethanol (100 mL), concentrated HCl (50 mL) and water (30 mL) was heated at reflux for three days. The volatile material was removed by evaporation and the residue was dried overnight. The residue was triturated with ethyl acetate, filtered and dried under a vacuum to give an amorphous powder (4.11 g, 68%).
Workup
- temperaturewas heated
- temperatureat reflux for three days
- customThe volatile material was removed by evaporation
- customthe residue was dried overnight
- customThe residue was triturated with ethyl acetate
- filtrationfiltered
- customdried under a vacuum
Sources & evidence
- ORD record
- ord-9b1f17d7df5240c1ad4150b61e22c110
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06696476B2
Reaction notes
Loading…