Phosphorus oxychloride → 3-Chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine

Reaction equation

[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[c:10](=[O:15])[nH:11][n:12][c:13]2[CH3:14])[cH:6][cH:7]1.[P:24]([Cl:25])([Cl:26])([Cl:27])=[O:28]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[c:10]([Cl:26])[n:11][n:12][c:13]2[CH3:14])[cH:6][cH:7]1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 450737225-(4-Chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazin-3(2H)-one

Product 1

HCID 450737233-Chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine

Sources & evidence

ORD record: ord-16a67abbeca1497ba26696ca921b1a89
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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