Bicarbonate Ion → 4-Chloro-2-(5-chloro-2-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidine

Reaction equation

[CH2:29]([Cl:30])[Cl:31].[Cl:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6](-[c:8]2[n:9][c:10]([OH:17])[c:11]3[c:12]([n:13]2)[CH2:14][O:15][CH2:16]3)[cH:7]1.[Na+:23].[O-:19][C:20]([OH:21])=[O:22].[P:24]([Cl:25])([Cl:26])([Cl:27])=[O:28]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6](-[c:8]2[n:9][c:10]([Cl:26])[c:11]3[c:12]([n:13]2)[CH2:14][O:15][CH2:16]3)[cH:7]1

Participants

Reactant 5

HCID 769Bicarbonate Ion

HCID 923Sodium Ion

HCID 6344Dichloromethane

HCID 24813Phosphorus oxychloride

HCID 178517510HCID 178517510, compound

Product 1

HCID 211043384-Chloro-2-(5-chloro-2-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidine

Sources & evidence

ORD record: ord-c9b0383c1319400fac46d3cb39cee5fc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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