1,2,3,4-Tetrahydroisoquinoline → 2-(3-Phenylisoxazol-5-yl)methyl-1,2,3,4-tetrahydroisoquinoline

Reaction equation

[Br:11][CH2:12][c:13]1[cH:14][c:15](-[c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[n:16][o:17]1.[CH2:1]1[NH:2][CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21.[CH3:24][CH2:25][O:26][C:27]([CH3:28])=[O:29].[CH3:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]>>[CH2:1]1[N:2]([CH2:12][c:13]2[cH:14][c:15](-[c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[n:16][o:17]2)[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21

Participants

Reactant 4

HCID 70461,2,3,4-Tetrahydroisoquinoline

HCID 8058Hexane

HCID 8857Ethyl Acetate

HCID 27487965-(Bromomethyl)-3-phenylisoxazole

Product 1

HCID 175310732-(3-Phenylisoxazol-5-yl)methyl-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record: ord-934d553096224ba7878f59ad1f3fd02f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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