Sodium ion → 2-Difluoromethoxy-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-benzonitrile

HRID 2130574

Reaction equation

HRID 2130574 reaction equation
[CH3:1][c:2]1[n:3][c:4](-[c:11]2[cH:12][cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[s:5][c:6]1[CH:7]([CH2:8][CH3:9])[OH:10].[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[F:23][CH:24]([O:25][c:26]1[c:27]([C:28]#[N:29])[cH:30][cH:31][c:32]([F:34])[cH:33]1)[F:35].[H-:21].[Na+:22].[OH2:36]>>[CH3:1][c:2]1[n:3][c:4](-[c:11]2[cH:12][cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[s:5][c:6]1[CH:7]([CH2:8][CH3:9])[O:10][c:32]1[cH:31][cH:30][c:27]([C:28]#[N:29])[c:26]([O:25][CH:24]([F:23])[F:35])[cH:33]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 166653HydrideHCID 235491291-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propan-1-olHCID 59295388HCID 59295388, compound

Product 1

HCID 595563432-Difluoromethoxy-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-benzonitrile

Sources & evidence

ORD record
ord-e605357fbbe84346ad44637732ace00c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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