Sodium Ion → 6-[2-(2-Chloro-5-methoxy-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

Reaction equation

[CH3:27][I:28].[Cl:1][c:2]1[c:3]([CH2:10][C:11](=[O:12])[c:13]2[cH:14][cH:15][c:16]3[c:17]([cH:24]2)[N:18]([CH3:23])[C:19](=[O:22])[CH2:20][O:21]3)[cH:4][c:5]([O:8][CH3:9])[cH:6][cH:7]1.[H-:25].[Na+:26].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[Cl:1][c:2]1[c:3]([CH:10]([C:11](=[O:12])[c:13]2[cH:14][cH:15][c:16]3[c:17]([cH:24]2)[N:18]([CH3:23])[C:19](=[O:22])[CH2:20][O:21]3)[CH3:27])[cH:4][c:5]([O:8][CH3:9])[cH:6][cH:7]1

Participants

Reactant 5

HCID 923Sodium Ion

HCID 6328Methyl iodide

HCID 8028Tetrahydrofuran

HCID 166653Hydride

HCID 666972226-[2-(2-chloro-5-methoxy-phenyl)-acetyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

Product 1

HCID 666972026-[2-(2-Chloro-5-methoxy-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

Sources & evidence

ORD record: ord-691ca624c0c04e5d992a27d1fdd7bb73
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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